Nucleus-specific abnormalities of GABAergic synaptic transmission in a genetic model of absence seizures Running title: GABAA IPSCs in GAERS
نویسندگان
چکیده
Acknowledgment: We wish to thanks Dr D.W. Cope for critical comments. This work was supported by the Fondation NRJ-Institut de France, the Wellcome Trust (grant 071436) and the Fondo de Investigaciones Sanitarias (grant 03/0177). D.R. is supported by the Ramón y Cajal program from MCYT, Spain. We wish to thank Novartis (Basel, Switzerland) for their gift of CGP 55845A and CGP 35348. Page 1 of 24 Articles in PresS. J Neurophysiol (September 13, 2006). doi:10.1152/jn.00682.2006
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Nucleus-specific abnormalities of GABAergic synaptic transmission in a genetic model of absence seizures.
Human and experimental studies indicate that molecular genetic changes in GABA(A) receptors may underlie the expression of spike-and-waves discharges (SWDs) occurring during absence seizures. However, the full spectrum of the genetic defects underlying these seizures has only been partially elucidated, the expression and functional profiles of putative abnormal protein(s) within the thalamocort...
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